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Tag Archive for: malaria

UT researchers discover bacterial genes that could lead to effective malaria treatment.

UT researchers discover bacterial genes that could lead to effective malaria treatment.

Researchers at the University of Tennessee, Knoxville, have identified a set of bacterial genes that may help them find ways to lessen the severity of the disease malaria.

Their findings could also aid the research of fellow scientists working in malaria-stricken regions around the world.

The study was published in the journal Frontiers in Microbiology.

Collaborators in this work include Steven Wilhelm, the Kenneth and Blaire Mossman Professor in the UT Department of Microbiology; Shawn Campagna, UT associate professor of chemistry; Gary LeCleir, UT research assistant professor of microbiology; Joshua Stough, UT doctoral student in microbiology; and Nathan Schmidt, assistant professor of microbiology and immunology at the University of Louisville.

The research team earlier this year released a study that found the severity of malaria depends not only on the parasite or the host but also on the microbes in the infected organism. They examined the gut microbiomes of mice.

This new study is helping researchers better understand how gut bacteria work.

Stough analyzed hundreds of genes and eventually found that 32 bacterial genes and 38 mice genes have the characteristics–or phenotypes–that can affect malaria.

“We’re pretty excited because it means there is a limited number of genes to work with,” Wilhelm said. That discovery will make it easier to find a more effective malaria treatment for people.

Much of the study was carried out in Wilhelm’s UT lab.

When the research team released the first study in February, scientists around the world doing similar microbiome work expressed interest.

“The findings in this second study could allow scientists to look at data they’re collecting and try to draw comparisons to see if what we’re seeing is also happening in their samples from malaria-stricken regions,” Wilhelm said. “We’re collecting data in a way that can be used to answer other questions after the fact.”

Hundreds of children die every year from malaria. “If we can find a way to mitigate this disease, we can positively influence a large number of people,” Wilhelm said.

Source: http://www.news-medical.net/

How Sri Lanka bit back at mosquitoes and wiped out malaria – podcast

How Sri Lanka bit back at mosquitoes and wiped out malaria – podcast

Sixty years ago, Sri Lanka was one of the countries most affected by malaria; in September 2016, the World Health Organisation declared the country free of the disease. Dinitha Rathnayake charts the journey of a huge victory for public health.

Dinitha Rathnayake, a radio journalist based in Colombo, looks back over Sri Lanka’s long struggle with malaria. She speaks to people who lived through the 1980s health crisis as well as the doctors, health workers and officials who helped to eliminate the disease.

Mahieash Johnney, of Sri Lanka’s Red Cross, looks back to the 1930s, when more than 5m cases of malaria were reported in the country.

Dr HDB Herath, the director of Sri Lanka’s Anti-Malaria Campaign, talks about what was involved in tackling the disease, from the use of insecticides to early detection through mobile health clinics.

The AMC’s SR Jayanetti discusses how the unique conditions of different regions affected malaria transmission – and how understanding this was a big part of the battle in containing it.

Finally, looking ahead to the challenge of maintaining Sri Lanka’s malaria-free status, Dr Anula Wijesundere, who saw the epidemic at first hand as a consultant at Polonnaruwa hospital from 1986 to 1989, talks of the danger of complacency and the vital importance of early diagnosis,

Source: theguardian.com

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