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Archive for month: February, 2016

Mosquito became world’s ‘most efficient killers’

Mosquito became world’s ‘most efficient killers’

It’s one of the most relentless stalkers on Earth, using a tiny, needle-like probe to sip its victims’ blood. It dines almost exclusively on humans and never ventures far from where they live, laying eggs in bottle caps, used tires and flower pots. It fits easily onto a single fingernail and yet has tormented armies and obliterated the population of entire cities.

Thousands of species of mosquitoes inhabit the planet, but few have proved more resilient — or more deadly to humans — than Aedes aegypti. It has fueled a long list of epidemics across the globe. Dengue fever. Yellow fever. Chikungunya. And now, Zika.

“It’s one of the most efficient killers in the world,” said Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine.

Aedes aegypti caused a punishing outbreak of yellow fever in the 1890s that hastened the French to abandon construction of the Panama Canal. It sickened thousands of soldiers during the Spanish-American War. It was behind deadly yellow fever outbreaks during the 19th century in New Orleans, Hampton Roads in Virginia and Memphis. Even now, it infects an estimated 20 million people around the world with dengue fever each year.

What makes Aedes aegypti such a formidable foe and such an efficient vessel for transmitting disease?

Partly biology and partly an uncanny ability to adapt. The species of mosquito, which is found in regions that are home to more than half of Earth’s population, has evolved to thrive in the places where humans congregate — particularly dense, urban environments rife with trash and open containers. It can breed in the smallest spots in and around homes. Its larvae don’t necessarily need water to survive, and eggs can lie dormant for a year or more, only to hatch once submerged in water. The sticky eggs glue themselves to containers as common and varied as the insides of old tires and the edges of birdbaths.

“It’s one of those pests, like cockroaches, that has evolved over the last 15,000 years to exploit changes in human behavior and habitation,” Ronald Rosenberg, acting director for the Division of Vector-Borne Diseases at the Centers for Disease Control and Prevention, said at a conference this past week. “It thrives around where people live in very close proximity.”

The World Health Organization recently described Aedes aegypti as “opportunistic,” with an uncanny ability to adapt to changing environments, exploit opportunities offered by increased international travel and rapid urbanization, and flourish “with striking efficiency” in impoverished areas.

Females — the only ones that bite — typically lay 100 to 200 eggs after each meal and can produce numerous batches of eggs in a lifetime. “Larvae have been found in a host of artificial containers, like discarded plastic cups and bottle caps, plates under potted plants, birdbaths, vases in cemeteries, and water bowls for pets,” the WHO said. “The mosquitoes can also breed in the microbial stew found in septic tanks, toilet tanks, and shower stalls. Construction sites, used tires, and clogged rain gutters offer additional opportunities to breed in large numbers.”

Aedes aegypti’s genetic makeup and feeding habits make it an ideal vector for spreading ­diseases such as the Zika virus among humans. Female mosquitoes, which feast on blood to provide protein to their eggs, take a “blood meal” from an already infected person. That blood then makes its way to the mosquito’s mid-gut area. In many mosquito species, the virus would remain stuck in the mid-gut, and the chain of transmission would end.

But Aedes aegypti possesses what entomologists call “vector competence.” In this case, it means that the virus replicates within the mosquito and finds its way back to the salivary glands — a process that can take days. When the mosquito then probes or bites another person, it transmits the virus to the new host.

“It doesn’t take much,” said Rebekah Kading, an entomologist and assistant professor at Colorado State University. “It’s a very biologically competent vector.”

Aedes aegypti mosquitoes are aggressive daytime biters, especially around dawn and dusk. They can hide under beds, in closets or in other shady places. They are “sip feeders,” meaning they feed often and on multiple hosts — a practice that makes it possible to spread disease quickly. They also are adept, experts say, at launching sneak attacks, in which they approach people from behind and bite them on the ankles and elbows to avoid being detected and slapped.

“It doesn’t have a very powerful bite,” said Joseph Conlon, technical adviser for the American Mosquito Control Association, a scientific nonprofit group based in New Jersey. “It can start feeding on your legs while you’re having your morning coffee, and you might not even know it. It can then quickly fly to someone else and feed on them. It’s very capable of transmitting the virus to many people.”

It wasn’t until the early 1900s that scientists confirmed that scourges such as yellow fever were being spread largely by the mosquitoes. In the decades since, humans have declared war more than once on Aedes aegypti, with some success. In the late 1940s and 1950s, for example, one campaign led to the eradication of Aedes aegypti in at least 18 Latin American countries and some Caribbean islands.

But the effort eventually faltered, as surveillance declined and political will waned. Mosquitoes developed resistance to insecticides, and urbanization outpaced eradication efforts. Aedes aegypti roared back, and so did diseases such as dengue fever.

“We’ve been fighting this mosquito for a century or more,” Kading said. “It’s a tough mosquito.” Aedes aegypti is one of many mosquitoes that torment humans. Certain species of the Anopheles mosquito can transmit malaria, which causes hundreds of thousands of deaths around the world each year. Mosquitoes of the Culex species are considered the primary vector for West Nile virus, which causes a potentially fatal neurological disease found in parts of Africa, Europe, the Middle East, North America and Asia. Other mosquito species carry an array of pathogens that are responsible for diseases including encephalitis and Rift Valley fever.

But as the Zika virus continues its rapid spread through the Americas, and as researchers become increasingly convinced of its links to brain defects in infants and a rare syndrome that can lead to paralysis in adults, health authorities are asking a question their predecessors have asked for generations: How can we combat Aedes aegypti?

The answer: It’s possible. But it’s neither cheap nor easy. “There’s a tremendous amount of human history that’s been influenced by this mosquito,” Conlon said. “It is one of the least of God’s creatures, but it can wreak such havoc on humans. And it has.”

BRAZIL ZAP Mosquitoes With GAMMA Rays

BRAZIL ZAP Mosquitoes With GAMMA Rays

To stop the spread of the Zika virus, the Brazilian government has tried numerous methods to slow the spread and control the population of the aedes mosquito, which spreads the virus. But as outbreak shows no hint of decline, officials may attempt a new approach: to sterilize millions of male mosquitoes by zapping them with gamma rays, according to a report today by Reuters.

The method would involve first breeding 12 million male mosquitoes a week, then sterilizing them by exposing them to gamma radiation using a device called an irradiator, and releasing them into target areas. Once there, the sterile males would mate with wild females, who would then lay dud eggs that don’t produce offspring.

The approach has already been used to control fruit flies in Madeira, an island off of Portugal, as well as other agricultural insect pests like screw worms and moths, according to the International Atomic Energy Agency (IAEA). If Brazil approves, the IAEA would ship the device to Juazeiro, a city in northeastern Brazil.

According to Reuters, the Brazilian government would first do a trial run in about a dozen towns near the city of Juazeiro. If successful, they would decide whether or not to scale up that approach and release the sterile mosquitoes to a wider area–possible by releasing them in the air via drones.

Similarly, in another attempt to breed sterile mosquitoes, a group of Brazilian researchers at the biomedical research institute are instead using radiation and releasing those mosquitoes off the coast of northeastern Brazil.
While researchers around the world are fervently trying to create a successful vaccine, none are available yet, and it’s still unclear when one will be ready.

Meanwhile, the virus continues to spread throughout Brazil and other areas in South America and cases of microcephaly, believed to be linked to Zika continue to increase. Whether or not this new approach will work remains to be seen, but Brazilian officials are desperate to stop the outbreak, especially as the 2016 summer Olympics which are set to be held in August in Brazil, creeps closer.

If all goes according to plan, though, zapping mosquitoes could prove to be a successful control method.

This Uncrushable Robot Cockroach

This Uncrushable Robot Cockroach

This Uncrushable Robot Cockroach

If you were trapped beneath a pile of rubble, a large robotic cockroach might be the last thing you’d hope to see scrabbling toward you. However, two researchers at the University of California, Berkeley, seem to think that such a contraption could be the ideal way to reach survivors buried under debris.

Robert Full, a professor at Berkeley, and one of his graduate students, Kaushik Jayaram, took inspiration from the remarkably squishable and resilient cockroach to develop a robot version with an exoskeleton that allows it be compressed to less than half its height in order to wriggle through confined spaces.

In a paper published today in the Proceedings of the National Academy of Sciences, Full and Jayaram show how a cockroach is able to squeeze its body into tight spaces and still keep moving, thanks to an exoskeleton made of soft materials. They conducted a series of experiments that involved compressing real cockroaches and observing the forces placed on them.

The researchers then built a device, which Full and Jayaram call a compressible robot with articulated mechanisms (CRAM), from several folding exoskeleton-like plates. They speculate that its malleability and strength could make it ideal for exploring collapsed buildings.

It’s a cool experiment that also points to a significant and newish trend in robotics. Many researchers and a few companies are becoming interested in soft or malleable robot designs for the various physical advantages they can offer.

Firms including Soft Robotics and Empire Robotics already sell soft grippers designed to make it easier for robots to manipulate objects without requiring extreme precision. Exoskeletons might offer another way to make robots that can change shape while still retaining their strength.

So next time you try in vain to crush a cockroach beneath your shoe, perhaps take a moment to marvel at its incredible design, and consider its potential applications.



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